Nanoparticles to Help Brain Injury Friday, Oct 3 2008 

Researchers from Purdue University have recently developed a new method of deliver treatments to brain injuries or spinal cord cells. They have combined silicon nanoparticles with a polymer (polyethylene glycol (PEG) and the antihypertensive drug hydralazine. This new method may be able to preserve both brain and spinal cord function after a person has undergone a traumatic brain injury when it is injected in specific brain area.

Borgens’ group had previously shown benefits of the polymer polyethylene glycol, or PEG, to treat rats with brain injuries and dogs with spinal cord injuries. PEG specifically targets damaged cells and seals the injured area, reducing further damage. It also helps restore cell function, Borgens said.

In the future researchers may increasingly get better at minimizing the damage associated with traumatic brain insults. They may also be able to repair that damage as well using stem cells.


PEG to Prevent Brain Damage Saturday, Jul 26 2008 

Science is working on better treatments that may be able to reduce brain damage that occurs after someone undergoes a brain injury.  Researchers have discovered that by injecting a polymer called polyethylene glycol into the brains of animals, they can reduce brain damage after the animals sustained a traumatic brain insult.

Polyethylene glycol (PEG; 2000 MW, 30% by volume) has been shown to mechanically repair damaged cellular membranes and reduce secondary axotomy after traumatic brain and spinal cord injury (TBI and SCI respectively). This repair is achieved following spontaneous reassembly of cell membranes made possible by the action of targeted hydrophilic polymers which first seal the compromised portion of the plasmalemma, and secondarily allow the lipidic core of the compromised membranes to resolve into each other.

This may eventually find use among human subjects. It could go a long way in reducing the damage that is the result of traumatic brain insults. Science is progressing towards minimizing brain damage and also repairing that brain damage as well.

Brain Injury Lawyer is a blog about brain disorders, brain injury, brain injury lawyers and brain injury law.